SS-31 10mg

Description

SS-31, also known as Elamipretide (C₃₂H₄₉N₉O₅; 639.8 g/mol), is a synthetic mitochondrial-targeted peptide developed by Hazel Szeto and Peter Schiller as a lead compound in their peptide series. This tetrapeptide (D-Arg-dimethylTyr-Lys-Phe-NH₂) is distinguished by its strong affinity for cardiolipin, a key lipid of the inner mitochondrial membrane, making it a valuable research tool for studying mitochondrial function and cellular bioenergetics.

Its alternating aromatic and basic amino acid structure allows SS-31 to cross cellular and mitochondrial membranes without the need for specific transporters, setting it apart from conventional antioxidants that distribute more broadly within cells. This selective targeting enables more precise investigation of mitochondrial processes, particularly those related to oxidative stress and energy production.

The identification of SS-31’s cardiolipin-binding properties has contributed to a deeper understanding of mitochondrial membrane dynamics and function. By focusing on the inner mitochondrial membrane—where cardiolipin plays both structural and functional roles—researchers can better examine how mitochondrial dysfunction contributes to various biological processes.

Due to its targeted mechanism, SS-31 is widely used in research exploring mitochondrial integrity, cellular energy systems, and oxidative stress across a range of experimental models. It remains an important compound for advancing the study of mitochondrial biology and related cellular mechanisms.

Reference

https://pubmed.ncbi.nlm.nih.gov/?term=ss-31

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