CJC-1295, Ipamorelin 10mg (Blend)

Description

Ipamorelin and CJC-1295 are both classified as growth hormone secretagogues (GHSs), compounds that stimulate the release of growth hormone (GH), though they differ in structure and pharmacokinetics. Ipamorelin is a synthetic pentapeptide that primarily acts on the growth hormone secretagogue receptor (GHS-R1a) in the hypothalamus and pituitary, selectively promoting GH release without significantly affecting other pituitary hormones like prolactin. CJC-1295, a 29-amino-acid peptide, is a modified analog of GHRH (1–29) designed to mimic natural GH-releasing hormone and enhance pituitary GH secretion.

Overview

Both peptides stimulate the anterior pituitary, promoting natural, pulsatile GH release and subsequent increases in IGF-1, which mediates many of GH’s anabolic and metabolic effects.

CJC-1295 is a tetrasubstituted GHRH 1–29 peptide with four amino acid modifications at positions 2, 8, 15, and 27. These substitutions improve resistance to enzymatic degradation and allow partial binding to plasma proteins such as albumin, extending its half-life from approximately 10 minutes to 30 minutes. When equipped with a Drug Affinity Complex (DAC), CJC-1295 can remain in plasma for over 72 hours, while retaining strong affinity for GHRH receptors.

Ipamorelin is highly selective for GHS-R1a receptors and can trigger GH release rapidly, typically within the first two hours of administration. Unlike other GHSs, it has minimal impact on other pituitary hormones, making it a targeted GH stimulator.

When used in combination—often called a peptide stack—Ipamorelin provides the initial GH stimulation, while CJC-1295 maintains sustained GH release, producing complementary and prolonged effects on the GH–IGF-1 axis.

Reference

https://pubmed.ncbi.nlm.nih.gov/?term=CJC-1295+%26+Ipamorelin

Storage & Molecular Integrity

Peptides are highly specific amino acid chains with delicate molecular structures. To maintain maximum biological activity and prevent degradation or aggregation (“gelation”), strict adherence to the following storage protocol is required:

• Total Light Protection
  Peptides are photosensitive. Store reconstituted vials in complete darkness. We recommend wrapping the vial in aluminum foil or using an opaque storage case.
• Refrigeration Required (35°F–46°F)
  After reconstitution, store vials in the back of the refrigerator. Do not store in the refrigerator door, as temperature fluctuations may compromise stability.
• Zero Agitation Policy
  Do not shake the vial. When reconstituting, allow bacteriostatic water to flow gently down the inside wall of the vial. Swirl slowly only if necessary. Excess agitation may damage peptide structure and reduce effectiveness.

⚠️  IMPORTANT: Failure to follow proper storage procedures may result in loss of potency and reduced performance.

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