Description

Bremelanotide, commonly referred to as PT-141, is a cyclic synthetic peptide composed of seven amino acids. It functions as an agonist of melanocortin receptors, similar to the naturally occurring hormone alpha-melanocyte-stimulating hormone (α-MSH). PT-141 is a metabolic derivative of Melanotan II and has been studied primarily for its potential effects on sexual function and reproductive physiology.

Overview

PT-141 interacts with melanocortin receptors MC3R and MC4R, influencing central nervous system activity:

• MC3R: Expressed primarily in the brain, especially the hypothalamus, MC3R is involved in energy homeostasis, metabolic regulation, and may influence feeding behavior, including appetite and nutrient intake. MC3R may also modulate the activity of other melanocortin receptors in the region.

• MC4R: Central to appetite regulation and energy expenditure, activation of MC4R may contribute to increased energy output and weight regulation. Research also suggests a role for MC4R in reproductive function, including modulation of penile tissue function and sexual behavior.

Experimental studies indicate that PT-141 binding to MC3R and MC4R can activate hypothalamic neurons, which in turn may stimulate sexual arousal in animal models. These findings have positioned PT-141 as a potential therapeutic agent for sexual dysfunction, with ongoing research exploring its broader physiological effects.

Reference

https://pubmed.ncbi.nlm.nih.gov/?term=pt141

Storage & Molecular Integrity

Peptides are highly specific amino acid chains with delicate molecular structures. To maintain maximum biological activity and prevent degradation or aggregation (“gelation”), strict adherence to the following storage protocol is required:

Total Light Protection
Peptides are photosensitive. Store reconstituted vials in complete darkness. We recommend wrapping the vial in aluminum foil or using an opaque storage case.
Refrigeration Required (35°F–46°F)
After reconstitution, store vials in the back of the refrigerator. Do not store in the refrigerator door, as temperature fluctuations may compromise stability.
Zero Agitation Policy
Do not shake the vial. When reconstituting, allow bacteriostatic water to flow gently down the inside wall of the vial. Swirl slowly only if necessary. Excess agitation may damage peptide structure and reduce effectiveness.

⚠️ IMPORTANT: Failure to follow proper storage procedures may result in loss of potency and reduced performance.

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